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Related Concept Videos

Activation of Integrins01:15

Activation of Integrins

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Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
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Integrins01:10

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Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
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Intracellular Signaling Affects Focal Adhesions01:17

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Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
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Cancer Stem Cells and Tumor Maintenance02:40

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
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Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
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Selectins01:25

Selectins

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Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
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Updated: Jun 14, 2025

A 3D Spheroid Model as a More Physiological System for Cancer-Associated Fibroblasts Differentiation and Invasion In Vitro Studies
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Integrins in cancer stem cells.

Siqi Gou1, Anqi Wu2, Zhigang Luo1

  • 1The Second Affiliated Hospital, Department of urology, Hengyang Medical School, University of South China, Hengyang, China.

Frontiers in Cell and Developmental Biology
|September 6, 2024
PubMed
Summary
This summary is machine-generated.

Integrins, cell adhesion receptors, play a key role in cancer progression. Targeting integrins in tumor stem cells offers a promising strategy for novel cancer therapies.

Keywords:
cancerintegrinstem cellstemnessstemness marker

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Area of Science:

  • Cell Biology
  • Cancer Biology
  • Molecular Medicine

Background:

  • Integrins are cell membrane adhesion receptors composed of α and β subunits.
  • They mediate cell-extracellular matrix interactions, activating intracellular signaling pathways crucial for cancer initiation and progression.
  • Tumor stem cells exhibit self-renewal, self-differentiation, and high tumorigenic potential.

Purpose of the Study:

  • To review the multifaceted role of integrins in cancer.
  • To specifically examine the impact of integrins on tumor stem cells and their stemness.
  • To highlight the therapeutic potential of targeting integrins in cancer treatment.

Main Methods:

  • Literature review and synthesis of existing research on integrins in cancer.
  • Focus on studies investigating integrin function in tumor stem cell biology.
  • Analysis of therapeutic strategies targeting integrins for cancer treatment.

Main Results:

  • Integrins are implicated in all stages of cancer development.
  • Integrin signaling pathways are critical for maintaining tumor stem cell properties (stemness).
  • Modulating integrin activity presents a viable approach to target tumor stem cells.

Conclusions:

  • Integrins are essential regulators of tumor stem cell behavior and cancer progression.
  • Targeting integrins offers a novel therapeutic avenue for eliminating cancer stem cells.
  • Further research into integrin-targeted therapies could lead to more effective cancer treatments.