Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Defense Against Bacterial Pathogens

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...

Defense Mechanism Against Infection

Defense Mechanism Against Infection

Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Growth-dependent tRNA Reprogramming and Codon Bias Link Translation to Metabolic State in <i>Enterococcus faecalis</i>.

bioRxiv : the preprint server for biology·2026

Same author

<i>Enterococcus faecalis</i> alters antibiotic susceptibility in <i>Pseudomonas aeruginosa</i> mixed-species biofilms.

Journal of bacteriology·2026

Same author

<i>Enterococcus faecium</i> colonization and persistence in a model of diabetic wound infection.

Infection and immunity·2026

Same author

A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

Adaptation of <i>Enterococcus faecalis</i> to intestinal mucus revealed by a human colonic organoid model.

mSystems·2026

Same author

Gelatinase regulates the egress of intracellular replicating populations during Enterococcus faecalis infection.

PLoS pathogens·2026

Same journal

Structure, assembly, and mechanism of the MmpL family of transporters.

Microbiology and molecular biology reviews : MMBR·2026

Same journal

Killer meiotic drivers in fungi.

Microbiology and molecular biology reviews : MMBR·2026

Same journal

From dividing to dormant: embracing the full activity spectrum for environmental microorganisms.

Microbiology and molecular biology reviews : MMBR·2026

Same journal

Role of TMDs in Class I viral fusion proteins.

Microbiology and molecular biology reviews : MMBR·2026

Same journal

The microbiome in reptile health, disease, and ecology.

Microbiology and molecular biology reviews : MMBR·2026

Same journal

Overcoming the energy-dependent barrier to aminoglycoside uptake: multimodal strategies to sensitize <i>Staphylococcus aureus</i> persisters.

Microbiology and molecular biology reviews : MMBR·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 14, 2025

Enteric Bacterial Invasion Of Intestinal Epithelial Cells In Vitro Is Dramatically Enhanced Using a Vertical Diffusion Chamber Model

Enteric Bacterial Invasion Of Intestinal Epithelial Cells In Vitro Is Dramatically Enhanced Using a Vertical Diffusion Chamber Model

Published on: October 22, 2013

Enterococcus faecalis: an overlooked cell invader.

Cristel Archambaud¹, Natalia Nunez¹, Ronni A G da Silva^2,3

¹Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, France.

Microbiology and Molecular Biology Reviews : MMBR

|September 6, 2024

Summary

This summary is machine-generated.

Enterococcus faecalis is a significant pathogen that can invade and replicate within host cells. Further research into these host-pathogen interactions is crucial for developing new infection prevention strategies.

Keywords:

Enterococcus Enterococcus faecalis Enterococcus faecium host-cell interactions intracellular lifestyle

More Related Videos

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates

Published on: February 17, 2023

Invasion of Human Cells by a Bacterial Pathogen

Invasion of Human Cells by a Bacterial Pathogen

Published on: March 21, 2011

Related Experiment Videos

Last Updated: Jun 14, 2025

Enteric Bacterial Invasion Of Intestinal Epithelial Cells In Vitro Is Dramatically Enhanced Using a Vertical Diffusion Chamber Model

Enteric Bacterial Invasion Of Intestinal Epithelial Cells In Vitro Is Dramatically Enhanced Using a Vertical Diffusion Chamber Model

Published on: October 22, 2013

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates

Published on: February 17, 2023

Invasion of Human Cells by a Bacterial Pathogen

Invasion of Human Cells by a Bacterial Pathogen

Published on: March 21, 2011

Area of Science:

Microbiology
Pathogenesis
Cell Biology

Background:

Enterococcus faecalis and Enterococcus faecium are pathobionts with dual commensal and pathogenic roles.
E. faecalis exhibits higher pathogenic potential than E. faecium, often linked to antimicrobial resistance.
E. faecalis is primarily considered an extracellular pathogen, adhering to and being internalized by mammalian cells.

Purpose of the Study:

To review current knowledge on Enterococcus faecalis-host cell interactions.
To highlight the emerging understanding of E. faecalis's intracellular lifestyle.
To emphasize the need for further mechanistic studies to combat E. faecalis infections.

Main Methods:

Literature review of studies on E. faecalis-host cell interactions.
Analysis of bacterial adhesion and internalization mechanisms.
Discussion of host cell receptors and bacterial evasion strategies.

Main Results:

Carbohydrate structures are key in E. faecalis adhesion to epithelial cells.
Internalization involves zipper-like and macropinocytosis pathways, with bacterial strategies to avoid phagocytosis.
E. faecalis can replicate intracellularly within various host cells, indicating an adaptable lifestyle.

Conclusions:

E. faecalis-host cell interactions, particularly the intracellular lifestyle, are not fully understood.
Mechanistic insights into E. faecalis pathogenesis are essential for effective prevention and treatment.
Further research is required to elucidate the complex interplay between E. faecalis and host cells.