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Expanding the insect defensin landscape
Krishnakoli Adhikary1, Sébastien F Poget2
1Department of Chemistry, College of Staten Island, City University of New York (CUNY), 2800 Victory Boulevard, Staten Island, NY 10314, USA; PhD Program in Chemistry, The Graduate Center, CUNY, 365 Fifth Avenue, New York, NY 10016, USA.
Abstract:
In this issue of Structure, Walker et al.1 determined the NMR structure of a recently discovered defensin, Pp19, from the venom of an assassin bug. This peptide adopts an α-defensin-like structure, which had not been observed in insects before. Unlike mammalian α-defensins, which are generally antimicrobial, Pp19 has insecticidal activity.
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