Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Training Global Leaders in Perioperative Equity: An Evaluation of the CHESA Fellowship.

World journal of surgery·2026
Same author

Pulse Oximeter Performance and Skin Pigment: Comparison of 34 Oximeters Using Current and Emerging Regulatory Frameworks.

Anesthesia and analgesia·2026
Same author

Kittredge Lecture: Pulse Oximetry Facts and Fallacies.

Respiratory care·2026
Same author

Expansion by the World Health Organization of the definition of medicinal oxygen for clinical use to narrow the oxygen availability gap.

Canadian journal of anaesthesia = Journal canadien d'anesthesie·2026
Same author

Pathways to Clinical Training Opportunities for International Medical Students and IMGs: The California Experience.

Annals of global health·2026
Same author

Comparing pulse oximeter performance using a common functional tester versus controlled desaturation studies on healthy participants.

Journal of clinical monitoring and computing·2025

Related Experiment Video

Updated: Jun 14, 2025

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
06:22

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS

Published on: April 7, 2021

3.4K

Pressure Control Surrogate Formula for Estimating Mechanical Power in ARDS Is Associated With Mortality.

Richard H Kallet1, Michael S Lipnick1

  • 1Mr. Kallet and Dr. Lipnick are affiliated with Department of Anesthesia and Perioperative Care, University of California, San Francisco at San Francisco General Hospital, San Francisco, California.

Respiratory Care
|September 6, 2024
PubMed
Summary

A simplified formula for respiratory system mechanical power (MP_RS) accurately predicts mortality risk in ARDS patients. Higher MP_RS levels consistently increased mortality risk by over twofold, aiding clinical assessment.

Keywords:
ARDSBerlin definitiondriving pressuremechanical powerplateau pressurepressure control ventilationventilator-induced lung injuryvolume control ventilation

More Related Videos

Lavage-induced Surfactant Depletion in Pigs As a Model of the Acute Respiratory Distress Syndrome ARDS
07:20

Lavage-induced Surfactant Depletion in Pigs As a Model of the Acute Respiratory Distress Syndrome ARDS

Published on: September 7, 2016

11.2K
Ex Vivo Porcine Experimental Model for Studying and Teaching Lung Mechanics
12:09

Ex Vivo Porcine Experimental Model for Studying and Teaching Lung Mechanics

Published on: April 19, 2024

1.4K

Related Experiment Videos

Last Updated: Jun 14, 2025

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
06:22

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS

Published on: April 7, 2021

3.4K
Lavage-induced Surfactant Depletion in Pigs As a Model of the Acute Respiratory Distress Syndrome ARDS
07:20

Lavage-induced Surfactant Depletion in Pigs As a Model of the Acute Respiratory Distress Syndrome ARDS

Published on: September 7, 2016

11.2K
Ex Vivo Porcine Experimental Model for Studying and Teaching Lung Mechanics
12:09

Ex Vivo Porcine Experimental Model for Studying and Teaching Lung Mechanics

Published on: April 19, 2024

1.4K

Area of Science:

  • Critical Care Medicine
  • Respiratory Physiology
  • Mechanical Ventilation

Background:

  • Mechanical power (MP) applied to the respiratory system (MP_RS) is a known risk factor for ventilator-induced lung injury (VILI) and mortality in ARDS patients.
  • Accurate MP_RS measurement is challenging due to the lack of automated ventilator integration, necessitating the use of complex equations or simplified surrogates.
  • Simplified surrogate formulas for MP_RS have shown accuracy comparable to established airway pressure-volume curve methods.

Purpose of the Study:

  • To evaluate the accuracy of a simplified pressure control surrogate equation for assessing mortality risk in ARDS patients.
  • To determine if this surrogate equation is effective in patients managed primarily with volume control (VC) ventilation.
  • To compare MP_RS levels between survivors and non-survivors across different ARDS severity classifications.

Main Methods:

  • Retrospective observational study of 948 ARDS patients receiving invasive mechanical ventilation within 24 hours of ARDS onset and surviving >24 hours.
  • MP_RS calculated using the formula: 0.098 x breathing frequency x tidal volume x (PEEP + driving pressure).
  • MP_RS assessed as a risk factor for hospital mortality, compared between non-survivors and survivors, and analyzed across four established thresholds (15, 20, 25, 30 J/min).

Main Results:

  • MP_RS was significantly associated with increased mortality risk (OR 1.06 [1.04-1.07], P < .001).
  • Median MP_RS levels were significantly higher in non-survivors compared to survivors across mild, moderate, and severe ARDS classifications (P < .001 to P = .034).
  • Mortality rates increased substantially (23-29% vs. 38-51%) when MP_RS exceeded established thresholds, with an odds ratio for mortality >2.0 in higher MP_RS groups.

Conclusions:

  • The simplified pressure control surrogate formula for MP_RS is accurate for assessing mortality risk in ARDS patients, including those on VC ventilation.
  • Exceeding established MP_RS cutoff values for VILI or mortality risk consistently increased patient mortality by over twofold.
  • This simplified formula offers a practical tool for clinicians to identify high-risk ARDS patients and potentially guide ventilation strategies.