Related Experiment Video
Updated: Jun 13, 2025

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
Published on: March 3, 2021
Successful Treatment of Risperidone-Induced Hypothermia With Aripiprazole: A Brief Case Report and a Literature
Ahmad Obeidat1, Feras Al-Moussally2, Waseem Abdallah3
1Department of Internal Medicine, MedStar Washington Hospital Center, Washington, DC, USA.
Abstract:
Hypothermia, a potentially fatal condition, can result from various internal causes, including certain medications. Antipsychotics, in particular, are associated with hypothermia, typically emerging 7-10 days after dosage adjustments. Here, we report the case of a 68-year-old male with a history of cerebral palsy, bipolar disorder, and paranoid schizophrenia who was admitted due to poor oral intake and was found to have persistent hypothermia despite active external rewarming. After substituting risperidone with aripiprazole, his temperature normalized, and he experienced no further hypothermic episodes. Antipsychotic-induced hypothermia should be considered in patients on these medications who present with non-specific symptoms. Regular monitoring of temperature and vital signs is crucial for early detection and management.
Related Concept Videos
Decreased Body Temperature
Methods of reducing fever
Pharmacological Methods of Reducing Fever:
Psychosis: Goals of Pharmacotherapy
Psychosis and Antipsychotic Drugs: Overview
Increased Body Temperature
Antipsychotic Drugs: Typical and Atypical Agents

