Prognostic Factors That Affect Mortality Patients with Acinetobacter baumannii Bloodstream Infection

Area of Science:

• Infectious Diseases
• Clinical Microbiology
• Critical Care Medicine

Background:

• Acinetobacter baumannii bloodstream infection (BSI) poses a significant clinical challenge.
• Understanding the clinical features and prognostic factors of A. baumannii BSI is crucial for patient management.

Purpose of the Study:

• To evaluate the clinical features of patients diagnosed with Acinetobacter baumannii bloodstream infection (BSI).
• To identify prognostic factors associated with 90-day mortality in A. baumannii BSI patients, including those with multidrug-resistant (MDR) strains.

Main Methods:

• Retrospective analysis of 200 inpatients with A. baumannii BSI.
• Comparison of clinical features between survival and mortality groups (30-day and 90-day).
• Analysis of differences between multidrug-resistant (MDR) and sensitive A. baumannii infections.
• Logistic regression and Kaplan-Meier analysis were used to determine prognostic factors and survival curves.

Main Results:

• Higher rates of carbapenem-resistant infection and ICU admission were observed in 90-day mortality patients.
• Elevated C-reactive protein (CRP) and serum creatinine (Scr), with lower red blood cells (RBC) and albumin (ALB), were associated with mortality.
• Critical surgery, ICU admission, and delayed antibiotic treatment were independent predictors of 90-day mortality.
• MDR A. baumannii infections were linked to longer ICU/hospital stays, altered laboratory values, and poorer overall survival compared to sensitive strains.

Conclusions:

• Critical surgery, ICU admission, delayed antibiotic treatment, and diabetes are significant risk factors for mortality in A. baumannii BSI.
• Multidrug-resistant A. baumannii infections are associated with worse clinical outcomes and prolonged hospitalizations.
• Implementing aggressive control strategies for MDR A. baumannii is essential for improving patient survival.