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Published on: July 17, 2020
Direct C-H amidation of 1,3-azoles: light-mediated, photosensitiser-free vs. thermal
David T Mooney1, Heather McKee1, Tabea S Batch1
1Institute of Chemical Sciences, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, UK. A.Lee@hw.ac.uk.
Abstract:
We have developed one thermal and one light-mediated method for direct Minisci-type C-H amidation of 1,3-azoles, which are applicable to thiazoles, benzothiazoles, benzimidazoles, and for the first time, imidazoles. The new visible light-mediated approach can be rendered photosensitiser/photocatalyst-free and likely proceeds via an electron donor-acceptor (EDA) complex, the first direct Minisci-type amidation to do so.
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