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Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice
Published on: August 9, 2013
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Acute Renal Infarction: A 12-Year Retrospective Analysis
Sheldon Greenberg1, Kundan Jana1, Kalyana Janga1
1Division of Nephrology, Maimonides Medical Center, Brooklyn, New York, USA.
Nephron
|September 9, 2024
Summary
Acute renal infarction (ARI) is a rare condition often missed. Cardiovascular issues like atrial fibrillation are common causes, and even anticoagulation may not prevent it.
Area of Science:
- Nephrology
- Cardiology
- Radiology
Background:
- Acute renal infarction (ARI) is uncommon and frequently underdiagnosed.
- Nonspecific symptoms and reliance on imaging for diagnosis.
- Understanding patient profiles and risk factors is crucial.
Purpose of the Study:
- To characterize the patient profile of acute renal infarction.
- To identify potential risk factors associated with ARI.
- To explore etiological categories of ARI.
Main Methods:
- Single-center retrospective observational study (2010-2022).
- Inclusion of inpatients diagnosed with ARI.
- Exclusion of chronic cases, iatrogenic causes, and non-radiographic evidence.
- Categorization into cardiovascular, hypercoagulable, and idiopathic groups.
Main Results:
- 85 patients included; mean age 61.6 years.
- Cardiovascular causes (49.4%), primarily atrial fibrillation (59.5%), were most frequent.
- Malignancy (69.3%) was the leading cause in the hypercoagulable group.
- Idiopathic group patients were younger with higher BMI.
- Smokers had significantly higher ARI risk.
- 48.2% of patients experienced ARI despite antiplatelet/anticoagulant therapy.
Conclusions:
- ARI is rare, underdiagnosed, and can lead to renal dysfunction.
- Consider ARI in young patients with risk factors, even if on anticoagulation.
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