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Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis
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RNA Modifications Shape Hematopoietic Stem Cell Aging: Beyond the Code

Inge van der Werf1, Jenna Sneifer1, Catriona Jamieson1

  • 1Sanford Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, California, 92037, USA.

FEBS Letters
|September 10, 2024
PubMed

Hematopoietic system aging is characterized by both hematopoietic stem cell (HSC) and niche degeneration resulting in myeloid lineage-biased differentiation, reduced B cell and T cell lymphopoiesis, increased HSC mobilization, and fat deposition in the bone marrow. Both alterations in RNA splicing and editing during HSC aging contribute to increased myeloid lineage skewing and inflammation-responsive transcription factors, underscoring the importance of epitranscriptomic mechanisms in the acquisition of an age-related phenotype.

Keywords:
ADAR1APOBEC3AgingHematopoiesisRNA EditingRNA SplicingStem Cells

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