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Interference of metamizole in the measurement of serum creatinine concentration
María-José Castro-Castro1,2, Isabel Cachón-Suárez1, Andrea Maestre-Fernández1,2
1Biochemistry Core, Laboratori Clínic Territorial Metropolitana Sud, Hospital Universitari de Bellvitge, Barcelona, Spain.
Objectives:
There is little literature on the interference of metamizole in measurement creatinine concentration by the enzymatic method. Some studies have postulated that the dipyrone molecule is responsible for interfering in the last reaction of the enzymatic method sequence, due to its similarity with the 4-aminophenazone molecule. The aim of this study is to examine the interference of the presence of metamizole in the measurement of serum creatinine concentration by the enzymatic method.
Methods:
An interference study of the measurement of creatinine concentration was carried out with two measurement procedures (enzymatic and Jaffe), by adding different concentrations of metamizole to pool from 30 serum samples of patients.
Results:
The interference study indicates that the results of serum creatinine concentrations in patients, as measured by the enzymatic method, decrease with the addition of increasing concentrations of metamizole.
Conclusions:
There is interference with metamizole in the measurement of serum creatinine concentration by the enzymatic method that it is have not seen in the Jaffe method.
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