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An Engineered Nisin Analogue with a Hydrophobic Moiety Attached at Position 17 Selectively Inhibits Enterococcus

Longcheng Guo1, Oscar P Kuipers1, Jaap Broos1

  • 1Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, 9747 AG, The Netherlands.

ACS Chemical Biology
|September 10, 2024
PubMed
Summary

A novel dual-action antibiotic, compound 47, was developed using nisin as a template. This modified lantibiotic shows enhanced specificity for *E. faecium*, improved stability, and retains nisin

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