Jove
Visualize
Contact Us

Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
  1. Home
  3. Functional-hydrogel-based Electronic-skin Patch For Accelerated Healing And Monitoring Of Skin Wounds.
  1. Home
  3. Functional-hydrogel-based Electronic-skin Patch For Accelerated Healing And Monitoring Of Skin Wounds.

Related Experiment Video

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management
08:50

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

Published on: September 2, 2015

8.8K

Functional-hydrogel-based electronic-skin patch for accelerated healing and monitoring of skin wounds.

Yoonsoo Shin1, Hyun Su Lee1, Jeong-Uk Kim2

  • 1Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, 08826, Republic of Korea; School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul, 08826, Republic of Korea.

Biomaterials
|September 10, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

This study presents a novel all-hydrogel electronic-skin (e-skin) patch for soft bioelectronics. The e-skin patch enables accelerated wound healing and monitoring through electrical stimulation and drug delivery, offering new possibilities for tissue interfacing.

More Related Videos

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

14.4K
Chessboard-like Burn Wound Healing Model of Mice Based on Digital Heating Device
04:04

Chessboard-like Burn Wound Healing Model of Mice Based on Digital Heating Device

Published on: December 27, 2024

468

Related Experiment Videos

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management
08:50

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

Published on: September 2, 2015

8.8K
Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

14.4K
Chessboard-like Burn Wound Healing Model of Mice Based on Digital Heating Device
04:04

Chessboard-like Burn Wound Healing Model of Mice Based on Digital Heating Device

Published on: December 27, 2024

468

Area of Science:

  • Materials Science and Engineering
  • Biomedical Engineering
  • Soft Electronics

Background:

  • Conductive hydrogels offer electrical performance and tissue-like softness for bio-integrated electronics.
  • Challenges remain in facile patterning and monolithic integration of functional hydrogels for all-hydrogel soft bioelectronics.

Purpose of the Study:

  • To report material design, fabrication, and integration strategies for an all-hydrogel electronic-skin (e-skin) patch.
  • To demonstrate the efficacy of the e-skin patch for accelerated wound healing and monitoring.

Main Methods:

  • Fabrication of an e-skin patch using photolithography-compatible functional hydrogels: PHEA (substrate), Ag flake (interconnection), PEDOT:PSS (working electrode), PDA (tissue adhesive), and PVA (encapsulation).
  • Characterization of hydrogel properties, including conductivity, impedance, and shear strength.
  • In vivo demonstration of accelerated wound healing and monitoring in mouse models using electric field stimulation and iontophoretic drug delivery.

    • Main Results:

    • The functional hydrogels mimic human tissue properties (water content, Young's modulus) for stable tissue-device interfacing.
    • Ag flake hydrogel achieved high conductivity (∼571.43 S/cm), PEDOT:PSS hydrogel exhibited low impedance (∼69.84 Ω @ 1 Hz), and PDA hydrogel showed high shear strength (∼725.1 kPa).
    • The e-skin patch successfully promoted fibroblast migration, proliferation, and differentiation, and enabled monitoring of accelerated wound healing via impedance mapping.

    Conclusions:

    • An all-hydrogel e-skin patch was successfully designed, fabricated, and integrated for soft bioelectronics.
    • The developed e-skin patch demonstrates significant potential for promoting and monitoring accelerated wound healing.
    • This technology is expected to open new avenues for clinically relevant tissue interfacing applications.