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The hormonal situation in the perimenopausal period
Acta Obstetricia Et Gynecologica Scandinavica. Supplement
|January 1, 1985
Summary
Ovarian follicular function begins in fetal development and ceases around menopause. Post-menopause, only ovarian stromal steroid production persists, influenced by gonadotropins.
Area of Science:
- Reproductive Endocrinology
- Gynecology
- Fetal Development
Background:
- Ovarian follicular function is a continuous process from fetal development through menopause.
- Luteal steroid production is restricted to the reproductive years.
- Post-menopause, ovarian stromal cells remain steroidogenically active.
Purpose of the Study:
- To describe the hormonal changes and effects during pre-, peri-, and postmenopausal periods.
- To elucidate the role of ovarian stromal steroid production after menopause.
Main Methods:
- Review of hormonal changes throughout the menopausal transition.
- Analysis of ovarian function in fetal, reproductive, and postmenopausal stages.
Main Results:
- Follicular function initiates in the 20th week of gestation and ends near menopause.
- Steroid production by the corpus luteum is limited to the fertile period.
- Ovarian stromal steroid production continues post-menopause, potentially elevated by increased gonadotropins.
Conclusions:
- Ovarian activity undergoes distinct phases: fetal follicular development, reproductive luteal function, and postmenopausal stromal activity.
- Hormonal shifts and their physiological impacts vary significantly across pre-, peri-, and postmenopausal stages.
- Understanding these ovarian changes is crucial for managing women's health through reproductive life and beyond.