RCDdb: A manually curated database and analysis platform for regulated cell death
Related Experiment Video
Updated: May 8, 2026
High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
Published on: November 9, 2020
Xiaopeng Wang1,2,3, Qing Wang4, Jun Zhao5
1State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China.
Abstract:
Regulated cell death is a pivotal regulatory mechanism governing the development and homeostasis of multicellular organisms. A comprehensive understanding of RCD's regulatory mechanisms is crucial for developing novel therapeutic strategies against diseases associated with cell death, such as cancer and neurodegenerative diseases. However, existing data repositories support limited types of cell death data and lack comprehensive annotation and analytical functionalities. Thus, establishing an extensive cell death database is an urgent imperative. To address this gap, we developed the Regulated Cell Death Database (RCDdb, chenyclab.com/RCDdb), the first comprehensively manually annotated database designed to support annotations and analytical capabilities across all RCD types. We compiled 3090 marker gene annotations associated with 15 RCD types from 2180 relevant articles. The RCDdb includes annotation data on these marker genes concerning diseases, drugs, pathways, proteins, and gene expressions. Furthermore, it provides 49 diverse visualization methods to present this information. More importantly, the RCDdb features three online analysis tools for identifying and analyzing RCD-related features within user-submitted data. Furthermore, the RCDdb offers a user-friendly interface for querying, browsing, analysis, and visualization of detailed information associated with each RCD category. This resource promises to significantly aid researchers in better understanding the mechanisms of cell death, thereby accelerating progress in research and therapeutic strategies aimed at combating RCD-related diseases.
Insights
A new database, RCDdb, catalogs regulated cell death (RCD) marker genes and offers analysis tools. This resource aids researchers in understanding cell death mechanisms for disease treatment.
Area of Science:
- Biomedical research
- Molecular biology
- Genomics
Background:
- Regulated cell death (RCD) is vital for multicellular organism development and homeostasis.
- Understanding RCD mechanisms is critical for treating diseases like cancer and neurodegenerative disorders.
- Current data repositories lack comprehensive RCD data and analytical tools.
Purpose of the Study:
- To establish the Regulated Cell Death Database (RCDdb), the first manually annotated database for all RCD types.
- To provide comprehensive annotations and analytical functionalities for RCD research.
Main Methods:
- Compiled 3090 marker gene annotations for 15 RCD types from 2180 articles.
- Integrated data on diseases, drugs, pathways, proteins, and gene expression.
- Developed 49 visualization methods and three online analysis tools.
Main Results:
- The RCDdb contains extensive manually curated annotations for RCD marker genes.
- It offers diverse visualization options and powerful online analysis tools.
- The database provides a user-friendly interface for data exploration and analysis.
Conclusions:
- RCDdb significantly enhances researchers' ability to study cell death mechanisms.
- This resource accelerates progress in developing therapeutic strategies for RCD-related diseases.
- RCDdb serves as a valuable platform for RCD research and drug discovery.
