Endometriosis and aspirin: a systematic review
Yi Yang1, HanHong Lai1, ZhengJuan Li2
1Department of Obstetrics and Gynecology, The Second Clinical Medical College, Jinan University, Shenzhen, China.
Frontiers in Endocrinology
|September 11, 2024
Summary
Aspirin may offer promise for endometriosis treatment, but current research is insufficient to confirm its effectiveness. More studies are needed to determine optimal aspirin use for endometriosis and infertility.
Area of Science:
- Reproductive Medicine
- Pharmacology
- Immunology
Background:
- Endometriosis is a common, inflammatory reproductive disorder affecting 10-15% of women.
- It is linked to infertility, pain, and significant economic burden.
- Pro-inflammatory cytokines are key characteristics of endometriosis.
Purpose of the Study:
- To review the relationship between endometriosis and aspirin.
- To explore aspirin's potential in improving reproductive outcomes for endometriosis patients.
- To investigate mechanisms linking endometriosis and inflammation.
Main Methods:
- A systematic literature search was performed using PubMed and Web of Science.
- Keywords included 'endometriosis' and 'aspirin'.
- Articles were screened by three independent reviewers based on inclusion/exclusion criteria.
Main Results:
- 72 articles were identified, with 10 selected for this review.
- The current body of evidence is limited.
Conclusions:
- Evidence is insufficient to establish aspirin as an effective endometriosis treatment.
- Further research is required to assess aspirin's efficacy, safety, and optimal dosage for endometriosis.
