Related Experiment Video
Updated: Jun 13, 2025

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
Published on: April 4, 2025
Updated guidelines for chronic kidney disease
1Becky Ness is an assistant professor of medicine at the Mayo Clinic College of Medicine, part of the Mayo Clinic Health System, Southwest Minnesota Region, in Mankato, Minn. Amy Mosman practices in nephrology at Saint Louis (Mo.) University. The authors have disclosed no potential conflicts of interest, financial or otherwise.
Abstract:
Chronic kidney disease (CKD) is an increasingly common condition worldwide that leads to substantial mortality. Research in the past decade has informed significant advances in preventing CKD or delaying its progression, mainly through new medications. This progress, however, requires adequate screening and identification of early CKD to truly transform patient outcomes. Revised guidelines from the Kidney Disease: Improving Global Outcomes consortium of experts aim to help clinicians incorporate these advances into practice. This article summarizes key updates from the guidelines regarding the evaluation and management of CKD that can lead to better patient outcomes.
Insights
New guidelines offer updated strategies for managing chronic kidney disease (CKD). Early screening and identification are crucial for leveraging recent medical advancements to improve patient outcomes in CKD.
Area of Science:
- Nephrology
- Internal Medicine
- Public Health
Background:
- Chronic kidney disease (CKD) is a global health concern with high mortality rates.
- Recent advancements in pharmacotherapy offer new avenues for CKD prevention and progression delay.
- Effective CKD management hinges on early detection and timely intervention.
Purpose of the Study:
- To summarize key updates from the revised Kidney Disease: Improving Global Outcomes (KDIGO) guidelines.
- To provide clinicians with practical guidance on incorporating recent CKD advances into practice.
- To enhance the evaluation and management of CKD for improved patient outcomes.
Main Methods:
- Review and synthesis of the latest KDIGO guidelines on CKD.
- Focus on practical recommendations for clinical application.
- Summarization of evidence-based strategies for CKD assessment and treatment.
Main Results:
- The updated guidelines emphasize the importance of early CKD screening.
- New treatment modalities and management approaches are detailed.
- The guidelines provide a framework for personalized CKD care.
Conclusions:
- Implementing updated KDIGO guidelines can significantly improve the diagnosis and management of CKD.
- Early identification and intervention are critical for mitigating CKD progression and mortality.
- These guidelines aim to translate research advancements into tangible benefits for patients with chronic kidney disease.
Related Concept Videos
Factors Affecting Renal Clearance: Renal Impairment
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Dialysis
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Nephrons
Chronic Pancreatitis II: Collaborative Care
Assessment:
Renal Clearance
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...

