Related Experiment Video

Updated: Jun 13, 2025

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
07:39

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

39

KIF18B: an important role in signaling pathways and a potential resistant target in tumor development

Shicheng Chen1, Bo Yu1, Guo Tu DU2

  • 1Department of Urology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, P. R. China.

Discover Oncology
|September 11, 2024
PubMed

Insights

Kinesin family member KIF18B promotes tumor growth and resistance to cancer treatments. Targeting KIF18B offers a promising strategy for developing new anticancer drugs and overcoming therapeutic resistance in malignant tumors.

Area of Science:

  • Molecular Biology
  • Oncology
  • Cell Biology

Background:

  • KIF18B, a kinesin-8 family member, regulates microtubule dynamics, spindle assembly, and chromosome alignment.
  • Dysregulation of KIF18B is implicated in various cellular processes and cancer development.

Purpose of the Study:

  • To review the structure, physiological functions, and role of KIF18B in malignant tumors.
  • To explore the association between KIF18B and key carcinogenic signaling pathways.
  • To evaluate KIF18B as a potential therapeutic target for cancer treatment.

Main Methods:

  • Literature review of studies on KIF18B structure, function, and cancer-related pathways.
  • Analysis of research linking KIF18B expression to tumor malignancy and treatment resistance.
  • Examination of signaling pathways including PI3K/AKT, Wnt/β-catenin, and mTOR in the context of KIF18B.

Main Results:

  • KIF18B plays a crucial role in microtubule dynamics and chromosome segregation.
  • Upregulation of KIF18B is associated with increased tumor malignancy and resistance to radiotherapy and chemotherapy.
  • KIF18B interacts with signaling pathways like PI3K/AKT, Wnt/β-catenin, and mTOR, contributing to tumorigenesis.

Conclusions:

  • KIF18B is a significant factor in promoting cancer progression and therapeutic resistance.
  • Targeting KIF18B presents a novel therapeutic strategy for treating malignant tumors.
  • Further research into KIF18B inhibition could lead to more effective anticancer drugs and overcome chemotherapy resistance.
Keywords:
KIF18BKinesins familyMTSignaling pathwaysTumorigenesis

More Related Videos

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays07:42

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays

Published on: September 19, 2018

7.9K
Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence10:09

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence

Published on: January 7, 2019

8.2K

Related Concept Videos

Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.2K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.8K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.4K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.3K
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
3.4K
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
7.4K