Related Experiment Video
Updated: May 7, 2026
07:46
Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus MRSA in Rat
Published on: June 4, 2012
15.7K
A case of Bartonella vinsonii endocarditis
Mengyuan Chen1, Yongjian Chen2, Xueqian He2
1The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Diagnostic Microbiology and Infectious Disease
|September 11, 2024
Summary
Diagnosing Bartonella infection, a rare cause of infective endocarditis, is difficult. Metagenomic Next Generation Sequencing (m-NGS) aided in early diagnosis and successful treatment, improving patient outcomes.
Area of Science:
- Infectious Diseases
- Cardiology
- Genomics
Background:
- Bartonella infections pose diagnostic challenges due to rarity and low culture yield.
- Delayed diagnosis of Bartonella can lead to severe complications like infective endocarditis, a potentially fatal condition.
Observation:
- A 60-year-old female presented with a 5-month history of recurrent fever, initially treated ineffectively.
- Clinical presentation and imaging suggested infective endocarditis.
- Metagenomic Next Generation Sequencing (m-NGS) identified Bartonella vinsonii as the causative agent.
Findings:
- Metagenomic Next Generation Sequencing (m-NGS) proved crucial in confirming Bartonella vinsonii infection when traditional methods failed.
- The patient recovered following surgical intervention and a combination antibiotic therapy including doxycycline and ceftriaxone sodium.
Implications:
- Integrating advanced diagnostics like m-NGS can overcome limitations in diagnosing rare infections such as Bartonella.
- Early and accurate diagnosis of Bartonella endocarditis is vital for timely and effective treatment, improving patient prognosis.
Related Concept Videos
01:25Endocarditis I: Introduction
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
01:25Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
01:18Endocarditis III: Medical Management
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
01:29Endocarditis IV: Nursing Management
Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
01:21Myocarditis I: Introduction
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
01:27Myocarditis II: Clinical Features and Diagnostic Tests
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...