Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

4.0K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinicopathological Characterization of Digital Papillary Adenocarcinoma With Emphasis on Low-risk Human Papillomavirus In Situ Hybridization and BRAF-VE1 Immunohistochemistry.

The American journal of surgical pathology·2026
Same author

Clinical, Imaging, Pathological, and Molecular Details of an Unusual Uveal Melanocytic Tumor of Childhood.

Ocular oncology and pathology·2026
Same author

TFG-Containing Fusions in Melanocytic Tumors: From Polymorphic Read-Through Transcripts to Oncogenic Kinase Fusions.

Journal of cutaneous pathology·2026
Same author

Clinical Outcomes and Prognostication of CRTC1::TRIM11 Fusion Cutaneous Tumors.

The American journal of surgical pathology·2026
Same author

Nonoperative Management of Locally Advanced Resectable Cutaneous Squamous Cell Cancer of the Head and Neck with PD-1 Blockade.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

PARP1 as a biomarker for differentiating melanoma from benign melanocytic lesions.

The Journal of investigative dermatology·2026

Related Experiment Video

Updated: Jun 13, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

15.7K

Desmoplastic melanoma.

Klaus J Busam1

  • 1Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Clinics in Dermatology
|September 11, 2024
PubMed
Summary

Desmoplastic melanoma, a rare fibrosing cancer, presents diagnostic challenges but offers a favorable prognosis for thick tumors. These melanomas often have high mutation burdens and respond well to immunotherapy when metastatic.

Area of Science:

  • Oncology
  • Dermatopathology

Background:

  • Desmoplastic melanoma is a rare, fibrosing variant of cutaneous melanoma.
  • It primarily affects elderly individuals but can occur in younger patients.
  • Its distinct histopathologic and clinical features can pose diagnostic challenges.

Purpose of the Study:

  • To highlight the diagnostic relevance of desmoplastic melanoma.
  • To discuss its unique clinical and histopathologic characteristics.
  • To review its prognostic implications and treatment response.

Main Methods:

  • Histopathologic analysis of desmoplastic melanoma cases.
  • Clinical data review including patient demographics and outcomes.
  • Review of mutation burden and response to immunotherapy.

More Related Videos

A Melanoma Patient-Derived Xenograft Model
07:07

A Melanoma Patient-Derived Xenograft Model

Published on: May 20, 2019

12.3K
Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

8.7K

Related Experiment Videos

Last Updated: Jun 13, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

15.7K
A Melanoma Patient-Derived Xenograft Model
07:07

A Melanoma Patient-Derived Xenograft Model

Published on: May 20, 2019

12.3K
Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

8.7K

Main Results:

  • Desmoplastic melanoma exhibits lower regional lymph node involvement than other melanoma types.
  • Thick desmoplastic melanomas generally have a more favorable prognosis.
  • Classic desmoplastic melanoma often presents with a high mutation burden.
  • Metastatic desmoplastic melanoma shows favorable responses to novel immunotherapies.

Conclusions:

  • Desmoplastic melanoma requires careful histopathologic differentiation due to its unique features.
  • It represents a distinct subtype with prognostic and therapeutic implications.
  • Its high mutation burden and immunotherapy responsiveness warrant further investigation.