Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Skeletal alterations in ovariectomized rats.

T J Wronski, P L Lowry, C C Walsh

    Calcified Tissue International
    |May 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effects of dried plum supplementation on bone metabolism in adult C57BL/6 male mice.

    Calcified tissue international·2013
    Same author

    Amelogenesis imperfecta and other biomineralization defects in Fam20a and Fam20c null mice.

    Veterinary pathology·2012
    Same author

    Enhanced alveolar bone loss in a model of non-invasive periodontitis in rice rats.

    Oral diseases·2012
    Same author

    Issues in modern bone histomorphometry.

    Bone·2011
    Same author

    Effects of increased hypothalamic leptin gene expression on ovariectomy-induced bone loss in rats.

    Peptides·2011
    Same author

    Effects of alendronate on bone healing after tooth extraction in rats.

    Oral diseases·2010

    Ovariectomy in rats caused significant bone loss and increased bone turnover. This surgical model reveals accelerated skeletal metabolism and bone remodeling following ovariectomy.

    Area of Science:

    • Bone biology
    • Endocrinology
    • Skeletal physiology

    Background:

    • Bilateral ovariectomy is a common surgical model to study estrogen deficiency.
    • Estrogen deficiency is a primary cause of postmenopausal osteoporosis.
    • Understanding the skeletal effects of ovariectomy is crucial for developing osteoporosis treatments.

    Purpose of the Study:

    • To investigate the effects of ovariectomy on bone mass, bone remodeling, and longitudinal bone growth in Sprague Dawley rats.
    • To quantify changes in bone histomorphometry following ovariectomy.

    Main Methods:

    • Female Sprague Dawley rats underwent either bilateral ovariectomy or sham surgery.
    • Tetracycline derivatives were used for bone formation labeling.
    • Proximal tibiae were analyzed using quantitative bone histomorphometry at 5 weeks post-surgery.

    Related Experiment Videos

    Main Results:

    • Ovariectomized rats showed a twofold decrease in trabecular bone volume.
    • Bone resorption and formation indices, including osteoclast and osteoblast surfaces/numbers, were elevated.
    • Calcification rate and longitudinal bone growth were also increased in ovariectomized rats.

    Conclusions:

    • Ovariectomy induces significant bone loss in the proximal tibial metaphysis.
    • The observed bone loss is associated with accelerated bone turnover, including both resorption and formation.
    • Ovariectomy serves as a valid model for studying accelerated skeletal metabolism and bone loss due to estrogen deficiency.