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Krüppel-like factors family in health and disease

Tingwen Xiang1, Chuan Yang2, Zihan Deng1

  • 1Department of Orthopedics Southwest Hospital Third Military Medical University (Army Medical University) Chongqing China.

Medcomm
|September 12, 2024
PubMed

Insights

Krüppel-like factors (KLFs) are key transcription factors impacting cell functions and diseases. This review details their roles in health, disease, and bone remodeling, offering insights for new therapies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Krüppel-like factors (KLFs) are transcription factors regulating cell proliferation, differentiation, and survival.
  • KLF dysregulation is linked to cardiovascular, metabolic, autoimmune, cancer, and neurodegenerative diseases.
  • KLFs play critical roles in skeletal system physiology and pathology.

Purpose of the Study:

  • To elucidate the multifaceted roles of KLFs in overall body health and disease.
  • To summarize KLF associations with cellular energy metabolism and epigenetic modifications in bone reconstruction.
  • To provide a comprehensive understanding of KLF functions in multiple systems and bone remodeling.

Main Methods:

  • Literature review and synthesis of existing research on KLFs.
  • Analysis of KLF involvement in various signaling pathways.
  • Examination of KLF roles in cellular energy metabolism and epigenetic modifications.

Main Results:

  • KLFs exhibit complex effects on cell functions and are implicated in numerous diseases.
  • KLFs are significantly involved in skeletal system development and homeostasis.
  • Associations between KLFs, energy metabolism, and epigenetics in bone remodeling were summarized.

Conclusions:

  • KLFs are pivotal regulators in physiological and pathological processes across multiple systems.
  • Understanding KLF mechanisms in bone remodeling can lead to novel therapeutic strategies.
  • Targeting the KLF family holds potential for treating various pathological conditions.
Keywords:
Krüppel‐like factors (KLFs)bone destruction diseasesbone homeostasisenergy metabolismepigenetic modificationsystemic diseases

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