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Updated: Jun 13, 2025

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Enamine Acylation Enabled Desymmetrization of Malonic Esters

Yu-Ping He1,2, Zhuo-Chen Li1, Zi-Qi Wang1

  • 1Shanghai Frontiers Science Center for Drug Target Identification and Delivery, National Key Laboratory of Innovative Immunotherapy, and Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.

Journal of the American Chemical Society
|September 12, 2024
PubMed
Summary

This study introduces the first enantioselective enamine acylation, a novel method for creating complex molecules. It utilizes chiral phosphoric acid catalysis for stereoselective synthesis of pyrrolinones and indolinones.

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