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Development and Evaluation of a Real-Time Phase-Triggered Stimulation Algorithm for the CorTec Brain Interchange.

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    |September 12, 2024
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    Summary
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    Researchers implemented a novel phase-triggered stimulation paradigm using the CorTec Brain Interchange and OMNI-BIC platform. This system reliably delivers phase-triggered stimulation, advancing adaptive neuromodulation research.

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    Area of Science:

    • Biomedical Engineering
    • Neuroscience
    • Medical Devices

    Background:

    • Biomarkers reflecting neural network state and clinical deficits drive interest in complex stimulation.
    • Current implantable neuromodulation systems have limitations hindering adaptive stimulation exploration.

    Purpose of the Study:

    • To implement and evaluate a phase-triggered stimulation paradigm.
    • To assess the performance of the CorTec Brain Interchange and OMNI-BIC platform for adaptive neuromodulation.

    Main Methods:

    • Utilized an investigational system, the CorTec Brain Interchange.
    • Employed the open-source software tool OMNI-BIC for phase-triggered stimulation.
    • Conducted performance evaluations through benchtop and in vivo human demonstrations.

    Main Results:

    • The Brain Interchange and OMNI-BIC platform demonstrated reliable administration of phase-triggered stimulation.
    • The platform showed capability for complex stimulation designs.

    Conclusions:

    • The CorTec Brain Interchange and OMNI-BIC platform is a viable tool for phase-triggered stimulation.
    • This platform has the potential to facilitate further research in adaptive neuromodulation design.