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Related Experiment Video

Updated: Jun 13, 2025

A Simple Non-invasive Method for Temporary Knockdown of Upper Limb Proprioception

A Simple Non-invasive Method for Temporary Knockdown of Upper Limb Proprioception

Published on: March 3, 2018

White matter disconnection impacts proprioception post-stroke.

Matthew Chilvers^1,2, Trevor Low^1,2, Deepthi Rajashekar^1,2

¹Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

|September 12, 2024

Summary

This summary is machine-generated.

Stroke survivors often experience proprioceptive impairments. This study reveals that damage to specific white matter tracts, including the superior longitudinal fasciculus and arcuate fasciculus, significantly impacts arm position matching performance post-stroke.

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Area of Science:

Neuroscience
Neurorehabilitation
White Matter Tracts

Background:

Proprioceptive impairments affect 50-64% of stroke survivors.
Understanding white matter's role in post-stroke proprioception is limited.
Behavioral deficits often stem from brain network disconnections.

Purpose of the Study:

To investigate white matter disconnection in relation to proprioceptive deficits after stroke.
To identify specific white matter tracts associated with impaired arm position matching.

Main Methods:

Assessed white matter lesion load and performance on a robotic arm position matching (APM) task in 203 stroke survivors.
Utilized neuroimaging and robotic assessments approximately 2 weeks post-stroke.
Examined disconnectome differences between participants with and without APM impairments.

Main Results:

Increased lesion load in the superior longitudinal fasciculus (SLF II and III), arcuate fasciculus, and fronto-insular tracts correlated with poorer APM performance.
Participants with APM impairments showed additional disconnection in the posterior corpus callosum, inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, and optic radiations.

Conclusions:

A perisylvian white matter network is crucial for proprioceptive processing post-stroke.
Identified key white matter tracts, beyond traditional pathways, involved in relaying proprioceptive information from parietal and frontal regions.