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Cyclophilin(g) a Knowledge Gap in Heart Failure Pathogenesis

Marion Delaunay1, Zegeye H Jebessa1, Timothy A McKinsey1

  • 1Department of Medicine, Division of Cardiology and Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora.

Circulation Research
|September 12, 2024
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Editorialsheart failureisomerismmyocardial infarctionventricular remodeling

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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
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