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Isolation of Double Negative αβ T Cells from the Kidney
Published on: May 16, 2014
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Double-negative T cells in pediatric rheumatic diseases
Dimitri Poddighe1,2,3, Tilektes Maulenkul1,2, Kuanysh Dossybayeva1
1Department of Medicine, Nazarbayev University School of Medicine (NUSOM), Astana, Kazakhstan.
Clinical and Experimental Pediatrics
|September 12, 2024
Summary
Double-negative (CD4-CD8-) T (DNT) cells are elevated in most pediatric rheumatic diseases, suggesting their potential role in these conditions. Further research is needed to confirm these findings in children.
Area of Science:
- Immunology
- Pediatrics
- Rheumatology
Background:
- Double-negative (CD4-CD8-) T (DNT) cells are known to be involved in autoimmune lymphoproliferative syndrome (ALPS).
- Emerging evidence suggests DNT cells possess immunomodulatory functions and may be altered in adult immune-mediated conditions.
Purpose of the Study:
- To systematically review existing literature on circulating DNT cells in pediatric rheumatic disorders outside of ALPS.
- To assess the current data regarding DNT cell levels in children with various rheumatic conditions.
Main Methods:
- A systematic literature review was conducted across PubMed, Scopus, and Web of Science.
- Eight studies (6 cross-sectional, 2 longitudinal) were included, encompassing diverse pediatric rheumatic diseases.
- Most studies included a control group for comparison.
Main Results:
- An increase in DNT cell numbers was observed in the majority of studies involving children with rheumatic diseases.
- The pooled patient population included children with pediatric systemic lupus erythematosus, juvenile idiopathic arthritis, Behçet's disease, and others.
- One study included children with high antinuclear antibody titers but no diagnosed rheumatic disease.
Conclusions:
- While DNT cells appear elevated in many pediatric rheumatic diseases, the limited number and heterogeneity of studies preclude definitive conclusions.
- Further well-designed clinical studies are warranted to elucidate the role of DNT cells in pediatric rheumatic conditions.
