Biochemical transformation and bioremediation of thallium in the environment

Thallium (Tl) is a toxic element associated with minerals, and its redistribution is facilitated by both geological and anthropogenic activities. In the natural environment, the transformation and migration of Tl mediated by (micro)organisms have attracted increasing attention. This review presents an overview of the biochemical transformation of Tl and the bioremediation strategies for Tl contamination. In the environment, Tl exists in various forms and originates from diverse sources. The global distribution characteristics of Tl in various media are summarized here, while its speciation and toxicity mechanism to organisms are elucidated. Interactions between (micro)organisms and Tl are commonly observed in the environment. Microbial response mechanisms to typical Tl exposure are analyzed at both species and gene levels, and the possibility of microorganisms as bio-indicators for monitoring Tl contamination is also highlighted. The processes and mechanisms involved in the microbial and benthic mediated transformation of Tl, as well as its enrichment by plants, are discussed. Additionally, in situ bioremediation strategies for Tl contamination and bio-treatment techniques for Tl-containing wastewater are summarized. Finally, the existing knowledge gaps and future research challenges are emphasized, including Tl distribution characteristics in the atmosphere and ocean, the key molecular mechanisms underlying Tl transformation by organisms, the screening of potential Tl oxidizing microorganisms and hyperaccumulators, as well as the revelation of global biogeochemical cycling pathways of Tl.