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The "Latines Lideres En Salud (LaLiSa)" study: Rationale and design.
Paola Torres1, Carolina Bujanda1, Juanita Arroyo2
1University of Illinois Chicago, 1200 W Harrison St, Chicago, IL 60607, USA.
Contemporary Clinical Trials
|September 12, 2024
Summary
This study tested strategies to increase cancer genetic services uptake among Latine women, addressing social determinants of health (SDOH) to improve breast cancer (BC) prevention equity.
Area of Science:
- Oncology
- Genetics
- Public Health
- Health Equity
Background:
- Latine women face higher breast cancer (BC) risks due to biological and social determinants of health (SDOH).
- Limited research exists on improving access to cancer genetic services for this population.
- Addressing SDOH is crucial for equitable precision cancer prevention.
Purpose of the Study:
- To compare the effectiveness of different strategies in increasing uptake of cancer genetic services among Latine women.
- To assess the impact of interventions on hereditary cancer risk assessment, genetic counseling, and genetic testing.
- To evaluate risk-based BC care strategies within the context of SDOH.
Main Methods:
- A study in Chicago recruited eligible Latine women aged 30+ with a personal/family history of BC and at least one SDOH risk.
- Participants were randomized into arms receiving phone-based education or empowerment sessions, alongside SDOH navigation and genetic services.
- Aim 2 involved network members of Aim 1 participants eligible for BC screening.
Main Results:
- Primary outcomes focused on the uptake of any cancer genetic services.
- Analyses explored intervention differences based on neighborhood context.
- Results will inform strategies for equitable access to genetic services.
Conclusions:
- This trial is among the first to focus on Latine participation in cancer genetic services and risk-based BC care.
- The findings have significant implications for advancing health equity in precision cancer prevention.
- Interventions addressing SDOH are vital for reducing disparities in cancer care.
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