A transdisciplinary systems-level approach to maternal health: Developing a Research Center of Excellence

The United States faces a critical maternal health crisis, characterized by the highest mortality rates among high-income nations and profound racial disparities. The University of Illinois Chicago established the Luma Center, a Maternal Health Research Center of Excellence funded by the National Institutes of Health IMPROVE initiative. This article details the center's development, implementation, and theoretical foundation. Central to the Luma Center's mission is the Biopsychosocial Ecosystem Framework, which shifts the research focus from individual-level factors to the multilevel systemic drivers of maternal morbidity and mortality. Utilizing a transdisciplinary approach involving 18 academic disciplines, the Center operates through five core areas: Leadership, Community Partnership, Research, Training, and Data. The primary objectives are to conduct robust multilevel research, cultivate a diverse research workforce, and strengthen community partnerships to ensure the translation of findings into effective postpartum interventions. By integrating community expertise with academic innovation, the Luma Center seeks to systematically address the fundamental causes of poor maternal health outcomes and advance science to promote perinatal health and wellness.