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Updated: Jun 13, 2025
Transdermal Measurement of Glomerular Filtration Rate in Mechanically Ventilated Piglets
Published on: September 13, 2022
[Current clinical application of glomerular filtration rate assessment methods in pediatric populations]
Zi-Sai Wang1, Sheng-Feng Wang1, Ming-Yi Zhao1
1Department of Pediatrics, Third Xiangya Hospital, Central South University, Changsha 410013, China(He Q-N, Email: heqn2629@csu.edu. cn).
Insights
Glomerular filtration rate (GFR) assessment in children is complex due to age-dependency and disease variations. This review clarifies pediatric renal function, GFR measurement, and equation applications for accurate clinical assessment.
Area of Science:
- Pediatric Nephrology
- Renal Physiology
- Clinical Chemistry
Background:
- Glomerular filtration rate (GFR) is a key marker for kidney function.
- Pediatric GFR shows age-dependent characteristics and differs from adult GFR, especially in disease states.
- Accurate GFR estimation is crucial for managing pediatric kidney diseases.
Purpose of the Study:
- To review the unique aspects of renal function in children.
- To explore various methods for measuring GFR in pediatric populations.
- To evaluate the clinical applicability of different GFR estimation equations in children.
Main Methods:
- Literature review of pediatric renal function.
- Analysis of GFR measurement techniques.
- Evaluation of GFR assessment equations in pediatric clinical practice.
Main Results:
- Pediatric renal function has distinct age-related patterns.
- GFR measurement methods and estimation equations require careful selection based on age and disease.
- Variability in methods can impact assessment accuracy.
Conclusions:
- Understanding pediatric renal function peculiarities is essential.
- Appropriate selection of GFR measurement and estimation methods is critical for accurate pediatric kidney function assessment.
- This review provides a reference for optimizing GFR assessment in children.
Abstract:
Glomerular filtration rate (GFR) is a critical indicator of renal function assessment, which exhibits age-dependency in children and may differ from adults under various disease conditions. In recent years, there has been a growing focus on GFR among scholars, with an increasing number of clinical studies dedicated to refining and optimizing GFR estimation to span all pediatric age groups. However, the methods and assessment equations for estimating GFR may vary under different disease conditions, affecting the accuracy and applicability of assessments. This article reviews the peculiarities of renal function in children, explores GFR measurement methods, and evaluates the application of various GFR assessment equations in pediatric clinical practice, providing a reference for clinical assessment of renal function in children.
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