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Updated: Jun 13, 2025
Oral Biofilm Formation on Different Materials for Dental Implants
Published on: June 24, 2018
Microbiome of diseased and healthy implants-a comprehensive microbial data analysis
Pingyi Jia1, Xinran Guo2, Jinchen Ye2
1Department of the Fifth Division, Peking University School and Hospital of Stomatology and National Center for Stomatology and National Clinical Research Center for Oral Diseases and National Engineering Research Center of Oral Biomaterials and Digital Medical Devices and Beijing Key Laboratory of Digital Stomatology and National Healty Center (NHC) Key Laboratory of Digital Stomatology and National Medical Products Administration (NMPA) Key Laboratory for Dental Materials, Beijing, China.
Peri-implantitis shows distinct submucosal microbial profiles compared to healthy implants, with increased species richness and specific bacterial genera like Treponema and Fretibacterium. Porphyromonas plays a key role in these dysbiotic communities.
Area of Science:
- Microbiology
- Bioinformatics
- Dental Implantology
Background:
- Peri-implant diseases, including peri-implant mucositis and peri-implantitis, are significant concerns in dental implantology.
- Understanding the submucosal microbial profiles associated with these conditions is crucial for diagnosis and treatment.
- Previous studies have utilized 16S rRNA gene sequencing to explore oral microbiome variations.
Purpose of the Study:
- To systematically analyze and compare the submucosal microbial compositions in healthy implants, peri-implant mucositis, and peri-implantitis.
- To identify differences in microbial diversity, flora composition, and key bacterial species across these conditions.
- To investigate the co-occurrence network patterns of submucosal microorganisms in peri-implant health and disease.
Main Methods:
- Systematic literature search of databases including PubMed, Embase, Scopus, CNKI, and Wanfang for studies using 16S rRNA gene sequencing.
- Bioinformatic analysis of downloaded high-throughput sequencing data to determine microbial diversity, community composition, and differential species.
- Re-classification of microorganisms using the Human Oral Microbiome Database (HOMD) and analysis of co-occurrence networks.
Main Results:
- Seven studies comprising 240 implants (51 healthy, 43 peri-implant mucositis, 146 peri-implantitis) were included.
- Significant differences in alpha and beta diversity were observed among the three groups.
- Genera *Treponema* and *Fretibacterium* were more abundant in peri-implantitis, while *Streptococcus* was more abundant in healthy implants. *Porphyromonas* abundance was 6.1% in peri-implantitis.
Conclusions:
- Submucosal microbial communities differ significantly between healthy implants and peri-implant diseases.
- Peri-implantitis is characterized by higher species richness and diversity, with increased abundance of 'red complex' and other periodontal pathogens.
- Distinct microbial community structures and co-occurrence network patterns are associated with healthy implants, peri-implant mucositis, and peri-implantitis, with *Porphyromonas* potentially playing a key role.
