Related Experiment Video
Updated: Jun 13, 2025
06:51
Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
33.2K
The Effects of Fisetin on Reducing Biological Aging: A Pilot Study
Alternative Therapies in Health and Medicine
|September 13, 2024
Summary
Fisetin, a natural senolytic compound, did not consistently reduce biological aging in healthy adults over 50. More research is needed before recommending fisetin for anti-aging purposes.
Area of Science:
- Gerontology
- Natural Compounds
- Aging Research
Background:
- Fisetin is a natural flavonoid with senolytic properties.
- Senolytic agents target and eliminate aging cells.
- Previous studies showed fisetin extended lifespan in mice.
Purpose of the Study:
- To investigate fisetin's effect on human biological aging.
- To determine if fisetin reduces biological age in adults over 50.
- To assess fisetin's efficacy as an anti-aging intervention.
Main Methods:
- Ten healthy adults over 50 received fisetin (500 mg daily for one week/month for six months).
- Biological aging was measured using the TruAge test.
- Telomere length was also monitored.
Main Results:
- Four out of ten participants showed reduced biological aging.
- Five out of ten participants showed increased biological aging.
- No statistically significant change in telomere length was observed.
- No adverse effects were reported.
Conclusions:
- Fisetin did not demonstrate consistent anti-aging effects in this study.
- The mixed results suggest further investigation is required.
- Fisetin is not recommended as an anti-aging agent at this time.
More Related Videos
Related Concept Videos
01:37Mitochondria
11.5K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
11.5K
01:19The Effect of Aging on Tissues
2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
01:26Aging
39
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
39
01:46Electron Transport Chain: Complex I and II
12.2K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
12.2K