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Near-Infrared Stimuli-Responsive Hydrogel Promotes Cell Migration for Accelerated Diabetic Wound Healing
Weijing Zhao1, Lei Qiang2, Changru Zhang3
1Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
ACS Applied Materials & Interfaces
|September 13, 2024
Summary
A novel near-infrared (NIR) responsive hydrogel dressing promotes diabetic wound healing. This dressing utilizes mechanical contraction and drug delivery to enhance cell migration and blood vessel formation for improved outcomes.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Wound Healing Research
Background:
- Diabetic wound healing, including diabetic foot ulcers, presents significant clinical challenges with high mortality and morbidity rates.
- Conventional wound dressings lack active modulation, limiting their efficacy in promoting the complex healing process.
- Effective strategies are needed to enhance cell migration, vascularization, and overall tissue repair in diabetic wounds.
Purpose of the Study:
- To develop a novel near-infrared (NIR) stimuli-responsive composite hydrogel dressing for enhanced diabetic wound healing.
- To investigate the synergistic effects of mechanical contraction and epithelial-mesenchymal transition (EMT) induction for improved wound closure.
- To evaluate the controlled release of Linagliptin (LIN) via NIR irradiation for biological stimulation and therapeutic benefits.
Main Methods:
- Fabrication of a methacrylated gelatin-based composite hydrogel incorporating N-isopropylacrylamide and polydopamine nanoparticles for thermosensitive and photothermal properties.
- Loading of Linagliptin (LIN) into the hydrogel, with drug release modulated by NIR laser irradiation.
- Assessment of the hydrogel's performance in a full-thickness skin defect model, evaluating wound closure rates under NIR stimulation.
Main Results:
- The developed composite hydrogel demonstrated NIR-triggered on-demand contraction and controlled LIN release, leveraging thermally induced sol-gel transition.
- Released LIN effectively promoted cell migration by activating EMT and enhanced angiogenesis, crucial for tissue regeneration.
- The LIN-loaded composite hydrogel with NIR irradiation exhibited the highest wound closure rate in the in vivo model compared to control groups.
Conclusions:
- The developed NIR-responsive composite hydrogel serves as a promising platform for promoting diabetic wound healing.
- The synergistic combination of mechanical contraction and targeted drug delivery offers a viable strategy for clinical applications.
- This innovative dressing has significant potential for improving patient outcomes in treating complex diabetic wounds.
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