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Updated: Jun 13, 2025
A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft
Published on: August 8, 2020
Preparation of sulfated arabinogalactan-loaded hydrogel for wound healing in mouse burn model
Shuai Zhang1, Wei Li2, Chuanbo Ding3
1College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China; Scientific and Technological Innovation Center of Health Products and Medical Materials with Characteristic Resources of Jilin Province, China.
Abstract:
Sulfation of polysaccharides can affect their biological activity by introducing sulfate groups. Skin burns occur regularly and have a great impact on normal survival. In this study, sulfated arabinogalactan (SAG) was prepared by sulfation, and polyvinyl alcohol (PVA) was used to prepare hydrogels for the treatment of scalded skin in mouse. The results show that the main chain of SAG consists of →3-β-D-Galactose (Gal)-(1, →3, 6)-β-D-Gal-(1 and →4)-β-d-Glucose (Glc)-(1. The chain is a neutral polysaccharide composed of T-β-L-Arabinose (Araf)-(1→, with a molecular weight of 17.9 kDa. At the same time, PVA + SAG hydrogel can promote the scald repair of mouse skin by promoting collagen deposition and angiogenesis, and regulating the TLR4/MyD88/NF-κB signaling pathway. Interestingly, the effect of SAG on promoting the repair of scald wounds is enhanced after AG is derivatized by sulfation. Therefore, the preparation of SAG by sulfation can promote scald repair, and has great application potential in the field of food and medicine.
