Essential Roles of PIEZO1 in Mammalian Cardiovascular System: From Development to Diseases

Area of Science:

• Cardiovascular Biology
• Mechanobiology
• Molecular Physiology

Background:

• Mechanical forces are fundamental to cardiovascular system function, development, and disease.
• The molecular mechanisms of cardiovascular mechanotransduction remain largely unknown.
• PIEZO1, a mechanosensitive ion channel, is expressed throughout the mammalian cardiovascular system.

Purpose of the Study:

• To review the role and mechanisms of PIEZO1 in cardiovascular mechanotransduction.
• To explore PIEZO1's involvement in various cardiovascular processes and diseases.
• To summarize PIEZO1-targeting molecules for potential therapeutic applications.

Main Methods:

• Literature review of PIEZO1's function in the cardiovascular system.
• Analysis of PIEZO1's role in cardiovascular development and homeostasis.
• Examination of PIEZO1's involvement in cardiovascular pathologies.

Main Results:

• PIEZO1 acts as a key mechanical sensor in the cardiovascular system.
• It influences embryo survival, angiogenesis, cardiac development, and repair.
• PIEZO1 is implicated in vascular inflammation, lymphangiogenesis, blood pressure, hypertrophy, fibrosis, remodeling, and heart failure.

Conclusions:

• PIEZO1 is a critical mediator of mechanical forces in the cardiovascular system.
• Understanding PIEZO1 mechanisms offers insights into cardiovascular diseases.
• Targeting PIEZO1 presents potential translational applications for cardiovascular therapies.