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Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
Published on: December 15, 2023
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Body Composition and Alzheimer's Disease: A Holistic Review
Giulia Frank1,2, Paola Gualtieri3, Rossella Cianci4,5
1PhD School of Applied Medical-Surgical Sciences, University of Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
International Journal of Molecular Sciences
|September 14, 2024
Summary
Alzheimer's disease (AD) is linked to body composition, especially obesity. Understanding these connections, including lean mass, bone mass, and inflammation, is crucial for AD prevention and treatment.
Area of Science:
- Neurology
- Gerontology
- Metabolic Research
Background:
- Alzheimer's disease (AD) affects 50 million globally, posing a significant health challenge.
- Obesity and altered body composition are increasingly recognized as potential contributors to AD pathogenesis.
- Existing literature highlights complex links between metabolic health and neurodegeneration.
Purpose of the Study:
- To systematically review and synthesize current research on the relationship between Alzheimer's disease and body composition.
- To focus specifically on the role of obesity, lean mass, bone mass, and associated factors in AD.
- To provide a comprehensive understanding of the multifactorial influences on AD development.
Main Methods:
- Systematic review of published literature.
- Searched electronic databases (PubMed, MEDLINE, Google Scholar) for relevant reviews.
- Keywords included: Alzheimer's disease, body composition, obesity, lean mass, bone mass, fat mass.
Main Results:
- Fifty-six relevant reviews were analyzed, revealing intricate correlations between AD and body composition.
- Key factors include lean mass, bone mass, endocrinological aspects of obesity, inflammation, neuroinflammation, and molecular/genetic elements.
- A complex interplay of these factors significantly influences AD development.
Conclusions:
- Holistic approaches are necessary to mitigate AD risk.
- Further research into innovative diagnostic, preventive, and therapeutic strategies is warranted.
- Understanding body composition's role is vital for comprehensive AD management.
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