Revolutionizing Bone Regeneration with Grinder-Based Dentin Biomaterial: A Systematic Review.

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Dental Surgery

Background:

• Alveolar bone defects due to resorption are common in dental surgery.
• Effective bone tissue regeneration is crucial for successful dental procedures.
• Dentin biomaterial is being investigated as a potential regenerative agent.

Purpose of the Study:

• To systematically review the evidence on the regenerative properties of dentin biomaterial.
• To summarize findings on dentin's efficacy in bone tissue regeneration, particularly in dental applications.
• To assess dentin's potential as a bone substitute.

Main Methods:

• Systematic review following PRISMA protocol.
• Searches in PubMed, Scopus, Web of Science, and gray literature.
• Inclusion of 13 articles focusing on laboratory, experimental, and clinical settings.

Main Results:

• Dentin composition is similar to bone, with key elements and a comparable Ca/P ratio.
• Chemically treated dentin is sterile, possesses characteristic tubules, and releases bone morphogenetic protein 2.
• Clinical studies show new bone formation and connective tissue increase after dentin transplantation, with uncomplicated healing.
• Gaps exist in data on complication rates and patient-reported outcomes.

Conclusions:

• Dentin biomaterial is a biocompatible and accessible bone substitute.
• Its preserved organic structure and growth factors enhance regenerative potential.
• Dentin-derived materials offer a promising alternative to autologous bone grafts in dental surgery, potentially reducing morbidity and costs.