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[Intracoronary thrombolytic therapy of myocardial infarction]
Insights
Intracoronary thrombolytic therapy using avelysine successfully recanalized coronary arteries in most acute myocardial infarction patients. This improved cardiac function and patient outcomes, reducing mortality.
Area of Science:
- Cardiology
- Interventional Cardiology
Background:
- Acute myocardial infarction (AMI) requires prompt restoration of blood flow.
- Intracoronary thrombolysis is a treatment option for AMI.
Observation:
- Avelysine was administered to 21 AMI patients on average 5.5 hours post-onset.
- Coronary artery recanalization was attempted via intracoronary thrombolysis.
Findings:
- Successful recanalization was achieved in 16 out of 21 patients.
- No deaths occurred in patients with successful recanalization.
- One death occurred in the 5 patients with failed recanalization attempts.
- Recanalization improved left ventricle function.
- Enzymatic shifts (creatine kinase and lactate dehydrogenase) were accelerated.
- Patients with successful recanalization experienced a milder disease course.
Implications:
- Intracoronary thrombolysis with avelysine is effective in AMI.
- Early recanalization improves cardiac function and clinical outcomes.
- This therapy reduces mortality and disease severity in myocardial infarction.
Abstract:
The results of intracoronary thrombolytic therapy with avelysine given to 21 patients with acute myocardial infarction are described. Intracoronary thrombolysis was performed on the average 5 h and 30 min after myocardial infarction onset. Recanalization of the coronary artery was attained in 16 patients, with no lethal outcomes. One patient died out of the 5, in whom attempts to recanalize the artery ended in failure. Recanalization of the coronary arteries led to improvement of left ventricle function and appreciably accelerated the time-course of the enzymatic shifts (KPK and LDH) in blood of myocardial infarction patients. After successful recanalization of the coronary artery the disease in myocardial infarction patients took a far milder course as compared to those who did receive intracoronary thrombolytic therapy.