Recent progress of protein kinase inhibitors derived from marine peptides for developing anticancer agents

Area of Science:

• Biochemistry
• Pharmacology
• Marine Biology

Background:

• Protein kinases are crucial in cell development and are targeted by anticancer drugs.
• Current protein kinase inhibitors face challenges like off-targeting and drug resistance.
• Marine anticancer peptides represent a new class of bioactive compounds with potential therapeutic applications.

Purpose of the Study:

• To review recent advancements in marine-derived anticancer peptides targeting protein kinases.
• To highlight peptides effective against resistant cancer cells by targeting novel kinase domains.
• To discuss the challenges and future prospects of marine peptides as anticancer agents.

Main Methods:

• Literature review of marine anticancer peptides and their mechanisms of action.
• Analysis of studies focusing on peptides targeting protein kinases.
• Examination of research on marine peptides inhibiting resistant cancer cells.

Main Results:

• Marine peptides demonstrate anticancer activity by inhibiting protein kinases.
• Specific marine peptides target novel domains within protein kinases, showing efficacy against resistant cancer cells.
• The review consolidates current knowledge on marine peptides as a promising anticancer strategy.

Conclusions:

• Marine anticancer peptides are a promising alternative to conventional therapies.
• Targeting novel domains of protein kinases with marine peptides can overcome drug resistance.
• Further research and development are needed to translate marine peptides into clinical anticancer agents.