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Related Experiment Videos

Multiple myeloma in three siblings.

L J Horwitz, R N Levy, F Rosner

    Archives of Internal Medicine
    |August 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Multiple myeloma, a plasma cell disorder, occurred in all three siblings of one family. This familial clustering suggests a potential hereditary basis, indicating other family members may be at increased risk.

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    Area of Science:

    • Hematology
    • Oncology
    • Genetics

    Background:

    • Multiple myeloma is a plasma cell malignancy.
    • Familial aggregation of multiple myeloma is rare but documented.
    • Monoclonal gammopathy can precede multiple myeloma development.

    Observation:

    • Three siblings in a single family were diagnosed with multiple myeloma.
    • Two siblings had a history of monoclonal gammopathy.
    • Rapid disease progression was noted in two of the affected siblings.

    Findings:

    • A literature review identified 38 sibling pairs with plasma cell disorders.
    • Eight of these families had a third affected sibling.
    • Four families reported another affected relative, suggesting familial clustering.

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    Implications:

    • The observed familial clustering supports a potential hereditary component in some multiple myeloma cases.
    • This suggests that genetic predisposition may play a role in disease development.
    • Family members of affected individuals may warrant increased surveillance for plasma cell disorders.