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New Insight in Using of Mesenchyme Stem Cell Conditioning Medium for the Impaired Muscle related Biomarkers: In vivo
Ronald Winardi Kartika1,2, Veronika Maria Sidharta2, Tena Djuartina2
1Department of Surgery, Faculty of Medicine and Health Sciences, Krida Wacana Christian University, West Jakarta, Indonesia.
Aims And Objectives:
This study aimed to investigate the effects of Umbilical Cord Mesencymal Stem Cell Conditioning Medium (UC MSC-CM) administration on body weight recovery and the level of four molecular biomarkers, namely Superoxide Dismutase (SOD), vascular Endothelial Growth Factor (VEGF), C-Reactive Protein (CRP), and myostatin.
Materials And Methods:
Secretome was injected intramuscularly twice at 1.5 mL (day 7 and 14) into the right thigh of high-dose, short-term galactose-induced aging rats. The data of day 7 (before) and day 21 (after the administration) were evaluated. The body weights and the four biomarkers were measured before (day 7) and after intervention (day 21).
Results:
This study showed that the UC MSC-CM intramuscular administrations did not influence body weight regeneration. However, it could increase SOD and VEGF levels and decrease CRP and myostatin levels.
Conclusion:
Treatment with UC MSC-CM is a promising and potential agent in treating sarcopenia.
