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Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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In vivo 19F MRI for Cell Tracking

In vivo 19F MRI for Cell Tracking

Published on: November 25, 2013

Quantitative in Vivo Molecular MRI.

Yingying Ning¹, Iris Yuwen Zhou², Peter Caravan²

¹Spin-X Institute, School of Chemistry and Chemical Engineering, School of Biomedical Sciences and Engineering, State Key Laboratory of Luminescent Materials and Devices, Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional Materials, South China University of Technology, Guangzhou, 510641, China.

Advanced Materials (Deerfield Beach, Fla.)

|September 16, 2024

Summary

This review guides chemists in developing quantitative molecular magnetic resonance imaging (MRI) probes. It details probe classification, validation methods, and quantitative analysis to advance non-invasive biological process imaging.

Keywords:

MRI contrast agent molecular imaging molecular probe quantitative imaging

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Area of Science:

Multidisciplinary field merging chemistry, biology, and imaging for non-invasive molecular event tracking.
Focuses on quantitative molecular MRI for reproducible biochemical target measurement.

Background:

Molecular MRI combines various scientific disciplines to visualize molecular processes.
Quantitative molecular MRI seeks to provide accurate, reproducible measurements of biological targets.

Purpose of the Study:

To provide guidance for developing and validating molecular MRI probes.
Aims to accelerate the translation of quantitative molecular MRI tools for biological imaging.

Main Methods:

Classifies molecular MRI probes by signal generation and function.
Discusses in vitro characterization and in vivo validation strategies, including bias avoidance.
Recommends imaging acquisition protocols and analysis for quantitative MRI signal interpretation.

Main Results:

Highlights representative case studies demonstrating successful quantitative molecular MRI.
Provides a framework for establishing quantitative relationships between probe signal and molecular processes.

Conclusions:

Quantitative molecular MRI is a complex, multidisciplinary endeavor.
Effective validation and quantitative analysis are crucial for advancing molecular MRI probe development and clinical translation.