Effect of Socialization on Alzheimer's Disease During the COVID-19 Pandemic

Age is the strongest risk factor for Alzheimer's disease, a neurodegenerative disease where beta-amyloid plaques accumulate in the brain. Elderly individuals, especially those in nursing homes, were burdened by social isolation during the COVID-19 pandemic. The purpose of this literature review is to describe the effectiveness of social engagement and how combating isolation can have a neuroprotective effect on individuals at risk for Alzheimer's disease. We conducted a search in PubMed examining articles from 2010 to 2023 that discussed the impact of socialization on Alzheimer's disease, particularly during the COVID-19 pandemic. Our search terms were "Alzheimer's Disease + Socialization," "Social Isolation + Alzheimer's Disease," "Alzheimer's Disease + COVID-19," "COVID-19 + Social Isolation," and "Social Interventions + Alzheimer's Disease." Inclusion criteria consisted of patients ages 60 and older with Alzheimer's disease, mention of social isolation or engagement, and any relationship between COVID-19 and Alzheimer's disease. Exclusion criteria were defined as other dementias, non-social interventions, and the effects of different viruses on Alzheimer's disease. After the screening process, 30 articles were included, along with six articles that were suitable to the topic. Of the 36 total articles, 19 focused on an intervention involving socialization; eight explored the effect of social isolation during COVID-19 on patients with Alzheimer's disease; five articles examined social isolation as a risk factor for dementia; and four articles discussed the effect of socialization on Alzheimer's disease. A few studies reported that having a large social network can improve cognition and mood for patients with Alzheimer's disease. Studies reported that interventions such as volunteering, video calls, group art classes, animal interactions, and others produced positive outcomes in Alzheimer's patients, but not all were statistically significant. Our review found a consistent association between a socially integrated lifestyle and a decreased incidence of early-onset dementia. Although not all interventions were solely social, a strong social structure remained at the core of a healthy aging process.