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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
Unveiling promising targets in gastric cancer therapy: A comprehensive review
Wenke Li1, Jing Wei1, Mo Cheng1
1Gastric Cancer Center/Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China.
Abstract:
Gastric cancer (GC) poses a significant global health challenge, ranking fifth in incidence and third in mortality among all malignancies worldwide. Its insidious onset, aggressive growth, proclivity for metastasis, and limited treatment options have contributed to its high fatality rate. Traditional approaches for GC treatment primarily involve surgery and chemotherapy. However, there is growing interest in targeted therapies and immunotherapies. This comprehensive review highlights recent advancements in GC targeted therapy and immunotherapy. It delves into the mechanisms of various strategies, underscoring their potential in GC treatment. Additionally, the review evaluates the efficacy and safety of relevant clinical trials. Despite the benefits observed in numerous advanced GC patients with targeted therapies and immunotherapies, challenges persist. We discuss pertinent strategies to overcome these challenges, thereby providing a solid foundation for enhancing the clinical effectiveness of targeted therapies and immunotherapies.
Insights
Gastric cancer (GC) treatments are advancing with targeted therapies and immunotherapies. This review explores their mechanisms, clinical trial efficacy, and strategies to overcome challenges for better patient outcomes.
Area of Science:
- Oncology
- Gastroenterology
Background:
- Gastric cancer (GC) is a leading cause of cancer incidence and mortality globally.
- Current treatments like surgery and chemotherapy have limitations, driving the need for novel therapeutic strategies.
Purpose of the Study:
- To provide a comprehensive review of recent advancements in targeted therapy and immunotherapy for gastric cancer.
- To analyze the mechanisms, clinical efficacy, and safety of these novel treatment modalities.
Main Methods:
- Systematic review of recent literature on gastric cancer targeted therapy and immunotherapy.
- Analysis of clinical trial data evaluating the efficacy and safety of these treatments.
- Discussion of challenges and strategies for enhancing clinical effectiveness.
Main Results:
- Targeted therapies and immunotherapies show significant potential in treating advanced gastric cancer.
- Clinical trials demonstrate varying degrees of efficacy and safety across different agents and patient populations.
- Several challenges remain in optimizing treatment response and overcoming resistance.
Conclusions:
- Targeted therapies and immunotherapies represent promising frontiers in gastric cancer treatment.
- Overcoming current challenges requires further research into predictive biomarkers and combination strategies.
- Enhanced clinical strategies are crucial for improving outcomes in gastric cancer patients.
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