Oral probiotic administration attenuates postexercise inflammation in horses
Robert D Jacobs1, Daniel Grum1, Benjamin Trible1
1Land O Lakes, Purina Animal Nutrition, Gray Summit, MO 63039, USA.
Translational Animal Science
|September 16, 2024
Summary
Bacillus coagulans GBI-30, 6086 supplementation reduced exercise-induced inflammation in horses. This probiotic may support equine health and performance by modulating inflammatory pathways.
Area of Science:
- Equine Nutrition and Exercise Physiology
- Microbiome and Immunology
Background:
- Probiotics are widely used in equine diets for health benefits, but scientific evidence for their efficacy in horses is limited.
- Bacteria from the Bacillus genus show potential in modulating metabolic, immune, and inflammatory pathways.
Purpose of the Study:
- To evaluate the efficacy of selected Bacillus probiotics in altering the inflammatory response to exercise in horses.
- To compare the effects of Bacillus coagulans GBI-30, 6086, Bacillus subtilis-1, Bacillus subtilis-2, and Bacillus amyloliquefaciens on post-exercise inflammation markers.
Main Methods:
- A randomized cross-over trial involving 18 horses, each receiving 6 treatments over 3-week phases.
- Treatments included a negative control, positive control (flunixin meglumine), and four Bacillus probiotics (8 billion CFU/d).
- Horses underwent a standardized 2-hour exercise test, with blood samples collected pre- and post-exercise for analysis of SAA, IL-6, and PGE2.
Main Results:
- Exercise significantly increased serum amyloid A (SAA), interleukin-6 (IL-6), and prostaglandin E2 (PGE2) concentrations post-exercise.
- Horses supplemented with Bacillus coagulans GBI-30, 6086 exhibited significantly reduced production of SAA, IL-6, and PGE2 compared to all other groups (P < 0.001).
- The positive control group demonstrated successful amelioration of the post-exercise inflammatory response.
Conclusions:
- Bacillus coagulans GBI-30, 6086 demonstrates significant potential in mitigating exercise-induced inflammation in horses.
- This probiotic may be a valuable addition to equine diets to support recovery from exercise and other inflammation-inducing challenges.
- Further research is warranted to elucidate the specific mechanisms underlying these observed anti-inflammatory effects.
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