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Updated: Jun 13, 2025
Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study
Published on: April 18, 2025
The current status and future trends of BET research in oncology
Siying Yu1, Linna Long1, Xiaorui Zhang1
1Department of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha, China.
Background:
BET family proteins are important epigenetic and transcriptional regulators involved in the control of tumorigenesis and development and have become important targets for cancer therapy. However, there is no systematic bibliometric analysis in this field. A visual analysis of the research hotspots and trends of BET is helpful to understand the future development direction.
Method:
We used CiteSpace, VOSviewer, and Excel to visualize and analyze the trends regarding authors, journals, countries or regions, highly cited papers, and keywords in the field.
Result:
The results included a total of 946 publications. There are many more papers on BET proteins published since 2013. The papers are mainly from 44 countries, led by the U.S. and China. A total of 7381 authors were identified, among which Bradner, J.E. had the greatest number of articles and the greatest influence. Cancer Discovery was the journal with the most citations per article. Our analysis identified the most influential papers in the field, including highly cited papers and citation burst references. The most frequent keywords included 'expression', 'c-Myc', 'cancer', 'BRD4', 'BET inhibition', 'resistance', 'differentiation', and 'JQ1', which represent the focus of current and developing research fields.
Conclusion:
Research on BET is thriving. Collaboration and exchanges between countries and institutions must be strengthened in the future, and the mechanisms of BET-related pathways, the relationship between BET and various diseases, and the development of new BET inhibitors have become the major focus of current research and the trend of future research.
Insights
This bibliometric analysis reveals the thriving research landscape of BET proteins, crucial epigenetic regulators and cancer therapy targets. Future research should focus on BET pathway mechanisms and novel inhibitor development.
Area of Science:
- Epigenetics and transcriptional regulation
- Cancer biology and therapy
- Bibliometric analysis of scientific literature
Background:
- BET family proteins are key epigenetic regulators in tumorigenesis and development.
- They represent important therapeutic targets in cancer treatment.
- A systematic bibliometric analysis was lacking for this field.
Purpose of the Study:
- To conduct a visual analysis of research hotspots and trends in the BET protein field.
- To understand the future development direction of BET research.
Main Methods:
- Utilized CiteSpace, VOSviewer, and Excel for bibliometric analysis.
- Analyzed trends in authors, journals, countries, highly cited papers, and keywords.
- Included 946 publications from 44 countries, primarily the U.S. and China.
Main Results:
- Research on BET proteins has significantly increased since 2013.
- J.E. Bradner was the most prolific and influential author.
- Key research areas include 'expression', 'c-Myc', 'cancer', 'BRD4', 'BET inhibition', 'resistance', 'differentiation', and 'JQ1'.
Conclusions:
- BET research is rapidly advancing, highlighting the need for enhanced international collaboration.
- Future research will concentrate on BET pathway mechanisms, disease associations, and novel inhibitor development.
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