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Updated: Jun 13, 2025

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
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Connective Tissue and Autoimmune Diseases Associated With Postsurgical Breast Augmentation: An Updated Review.

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Summary

Breast augmentation, particularly with silicone implants, is linked to various autoimmune connective tissue diseases (CTDs). Explantation may help symptoms, but research is ongoing to understand the exact causes and improve patient care.

Keywords:
autoimmune connective tissue disorders (ctds)breast implantconnective tissue disorderimplant-based breast augmentationreconstructive breast surgerysystemic lupus erythema

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Area of Science:

  • Medical Science
  • Rheumatology
  • Plastic Surgery

Background:

  • Breast augmentation is a common cosmetic procedure.
  • Concerns exist regarding potential associations between breast implants and connective tissue diseases (CTDs).
  • Previous literature suggests a link, but the relationship remains debated.

Purpose of the Study:

  • To provide an updated overview of the association between breast augmentation and CTDs.
  • To review recent literature on autoimmune disorders reported in patients with breast implants.
  • To discuss the history, associated illnesses, and treatment of CTDs in this context.

Main Methods:

  • A narrative review of recent scientific literature was conducted.
  • Studies reporting autoimmune disorders in patients with breast implants were analyzed.
  • Literature on implant technology, patient outcomes, and long-term health implications was examined.

Main Results:

  • Various autoimmune disorders, including Raynaud's syndrome, rheumatoid arthritis, and Sjögren's syndrome, have been reported with breast implants, especially silicone ones.
  • Systemic symptoms such as fatigue, joint pain, and rashes are common.
  • Explantation has shown potential for symptom relief, though the underlying mechanisms are not fully understood.

Conclusions:

  • The association between breast implants and CTDs is complex and requires further investigation.
  • Informed consent, vigilant monitoring, and multidisciplinary care are crucial for patients.
  • Continued research is essential to clarify risks and develop evidence-based guidelines for patient management.