Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Combining Supramolecular and Covalent Chemistry to Form Reinforced Fibrillar Network Hydrogels From Fibrinogen Derivatives.

Journal of biomedical materials research. Part A·2026

Same author

Injectable Hydrogel-Based Delivery of Soluble Cripto Protein Enhances Repair After Skeletal Muscle Injury.

ACS biomaterials science & engineering·2026

Same author

Cuttlefish Ink-Derived Melanin Nanoparticles Enabling NIR-Responsive Electrospun Nanofibrous Mats for On-Demand Selective Antibacterial Disinfection of Orthodontic Braces.

ACS applied materials & interfaces·2026

Same author

Immune Cell Composition and Protein Biomarkers Correlate With PRP Treatment Outcomes in Knee Osteoarthritis.

Orthopaedic journal of sports medicine·2026

Same author

Single-cell transcriptomics-informed induced pluripotent stem cells differentiation to tenogenic lineage.

eLife·2026

Same author

Body image perception and emotional awareness in adults with celiac disease: A cross-sectional study.

Medicine·2026

Same journal

Spiky Magnetic Titania Particles for Integrated Exosome Capture and Metabolic Profiling Toward Cancer Diagnosis.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same journal

Versatile Targeted Celastrol Nanoassemblies for Enhanced Immunomodulatory Effects Against MRSA Infection.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same journal

Submicron Cu(In,Ga)Se<sub>2</sub> Solar Cells With Over 20% Efficiency Enabled by Novel Construction of U-Shape Ga-Gradient.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same journal

Brønsted Acid-Driven Dynamic LMCT Sites Transform Pt/Zeolite Into a Light-Responsive Oxidation Platform.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same journal

Self-Powered Triboelectric Nanogenerators in Intelligent Food Packaging: Recent Advances and Applications.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same journal

Vanadium Nitride Quantum-Dot Bidirectional Catalysis for Accelerated Polysulfide Redox in Room-Temperature Na-S Batteries.

Small (Weinheim an der Bergstrasse, Germany)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 24, 2026

Electrospinning Growth Factor Releasing Microspheres into Fibrous Scaffolds

Electrospinning Growth Factor Releasing Microspheres into Fibrous Scaffolds

Published on: August 16, 2014

Injectable PLGA Microscaffolds with Laser-Induced Enhanced Microporosity for Nucleus Pulposus Cell Delivery.

Paweł Nakielski¹, Alicja Kosik-Kozioł¹, Chiara Rinoldi¹

¹Department of Biosystems and Soft Matter, Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, 02-106, Poland.

Small (Weinheim an Der Bergstrasse, Germany)

|September 16, 2024

Summary

This summary is machine-generated.

New microscaffolds improve cell delivery for lower back pain. Laser-structured poly(lactic-co-glycolic acid) microscaffolds enhance human nucleus pulposus cell survival and retention for potential disc degeneration therapies.

Keywords:

cell carrier electrospinning injectable biomaterials laser‐assisted microfabrication nucleus pulposus

More Related Videos

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Published on: September 7, 2017

Fabricating Highly Open Porous Microspheres HOPMs via Microfluidic Technology

Fabricating Highly Open Porous Microspheres HOPMs via Microfluidic Technology

Published on: May 16, 2022

Related Experiment Videos

Last Updated: Apr 24, 2026

Electrospinning Growth Factor Releasing Microspheres into Fibrous Scaffolds

Electrospinning Growth Factor Releasing Microspheres into Fibrous Scaffolds

Published on: August 16, 2014

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Published on: September 7, 2017

Fabricating Highly Open Porous Microspheres HOPMs via Microfluidic Technology

Fabricating Highly Open Porous Microspheres HOPMs via Microfluidic Technology

Published on: May 16, 2022

Area of Science:

Biomaterials Science
Regenerative Medicine
Orthopedics

Background:

Intervertebral disc (IVD) degeneration causes lower back pain (LBP).
Current treatments manage symptoms but do not halt degeneration.
Cell transplantation shows promise but faces challenges in cell viability, retention, and the host environment.

Purpose of the Study:

To compare the injectability and biocompatibility of human nucleus pulposus cells (hNPC) on two types of microscaffolds.
To assess microscaffolds for minimally invasive delivery into the IVD.
To evaluate the potential of these microscaffolds for cell-based LBP therapies.

Main Methods:

Poly(lactic-co-glycolic acid) (PLGA) microscaffolds were fabricated using electrospinning and femtosecond laser structuration.
Physical properties, injectability, and biocompatibility were tested.
Cell adhesion, proliferation, and survival were evaluated in vitro and ex vivo using a hydrogel-based nucleus pulposus model.

Main Results:

Microscaffolds exhibited enhanced surface architecture, promoting cell adhesion and proliferation.
Laser structuration improved porosity, aiding cell attachment and extracellular matrix deposition.
Microscaffolds were successfully delivered via small-gauge needles with high cell viability.

Conclusions:

Laser-structured PLGA microscaffolds are suitable for minimally invasive cell delivery to the IVD.
These microscaffolds improve cell viability and retention, crucial for effective cell-based therapies.
This technology offers potential advancements for treating discogenic lower back pain.