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Related Experiment Videos

Tocainide: a new oral antiarrhythmic.

G R Hasegawa

    Drug Intelligence & Clinical Pharmacy
    |July 1, 1985
    PubMed
    Summary

    Tocainide, an oral antiarrhythmic drug, effectively controls chronic ventricular arrhythmias, especially in patients responsive to lidocaine. It offers an alternative for those intolerant to other treatments, though side effects like gastrointestinal and neurological issues are common.

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    Area of Science:

    • Pharmacology
    • Cardiology
    • Clinical Therapeutics

    Background:

    • Tocainide is an orally active analog of lidocaine used for ventricular arrhythmias.
    • It exhibits similar electrophysiological properties to lidocaine with minimal hemodynamic impact.

    Purpose of the Study:

    • To review the efficacy and safety profile of tocainide in managing ventricular arrhythmias.
    • To identify patient populations who may benefit most from tocainide therapy.

    Main Methods:

    • Review of existing clinical data and pharmacological studies on tocainide.
    • Analysis of pharmacokinetic properties, including oral bioavailability and elimination half-life.
    • Evaluation of reported side effects and therapeutic comparisons with other antiarrhythmic agents.

    Main Results:

    • Tocainide demonstrates high oral bioavailability and a half-life of 11-15 hours, with 40% excreted unchanged.
    • Common side effects include gastrointestinal and neurological disturbances, generally well-tolerated.
    • Effective in controlling chronic ventricular arrhythmias, particularly in lidocaine-responsive patients.
    • Not superior to quinidine or procainamide; may worsen heart failure or cause rash.

    Conclusions:

    • Tocainide is a valuable option for patients with chronic ventricular arrhythmias unresponsive to other treatments or those who cannot tolerate alternative antiarrhythmics.
    • Its effectiveness is notable in patients with a history of lidocaine responsiveness or Q-T prolongation.
    • Careful monitoring for side effects is essential during tocainide therapy.

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