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Heparin-induced skin necrosis.

Drug Intelligence & Clinical Pharmacy

|April 1, 1984

Summary

This summary is machine-generated.

Subcutaneous heparin can cause skin necrosis, a serious adverse reaction. Discontinue heparin if necrosis develops and consider alternative treatments to manage this complication.

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Area of Science:

Pharmacology
Dermatology
Hematology

Background:

Heparin is a widely used anticoagulant to prevent and treat thromboembolic events.
Subcutaneous administration is a common route for long-term heparin therapy.

Observation:

A case report details a 76-year-old woman who developed skin necrosis after receiving subcutaneous heparin for deep vein thrombosis prophylaxis.
Necrotic lesions appeared on the abdomen 19 days after initiating heparin therapy.

Findings:

The patient's heparin injections were stopped upon observation of skin necrosis.
Subsequent intravenous heparin administration did not cause complications, suggesting localized reaction to subcutaneous administration.
Proposed mechanisms include allergic vasculitis or localized platelet aggregation leading to intravascular thrombosis.

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Implications:

Heparin-induced skin necrosis necessitates immediate cessation of the drug.
Alternative anticoagulation strategies may be required for patients experiencing this adverse effect.
Steroids and other agents might play a role in preventing or managing heparin-induced skin necrosis.